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Novel Biomolecules Modulating Innate Immune Responses against Virus Infection

Amit Kumar Rai

Topic Information

Dear Colleagues,

The innate immune response against viruses is fundamental for the host to survive infections. Foreign viral pathogens are sensed by a set of germline-encoded pattern-recognition receptors triggering a rapid response, including a variety of defense mechanisms, such as DNA damage response, cellular stress response pathways, inflammasome pathways or regulated cell death responses. Central to the innate host defense is the type I interferon pathway inducing antiviral proteins to control infection and alert other cells. These innate responses are observed at the intra-cellular, tissue and systemic level. The responses not only include the activity of proteins, positive and negative regulators of the innate signaling cascades, but are also regulated by lipids, polysaccharides, nucleic acids and other metabolites.

This Special Issue aims to highlight novel involvement of all kinds of biomolecules in the innate response to mammalian virus infections, including, but not limited to, second messengers, miRNAs, nucleotides and novel cellular factors. These biomolecules may modulate intracellular innate signaling, affect cell–cell communication or change the biology of the host cell. The biomolecules could interfere with cellular signaling responding to viruses, could directly target or repress viruses at any stage or indirectly regulate dependency or restricting proteins or protein complexes.

We encourage the submission of reviews but also welcome original research papers.


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